Thyroid Function Tests in Patient with Ischemic Stroke
Kerbala Journal of Medicine,
2013, Volume 6, Issue 2, Pages 1694-1702
Abstractbjectives: To analyze thyroid functions tests in patients with ischemic stroke at acute stage and to study the association between ischemic stroke and different types of thyroid dysfunctions.
Methods: A hospital based, cross-sectional, case-control study with trial to cancel the role of age, gender, hypertension and diabetes mellitus as confounding factors was adopted to achieve the aim of this study. A total number of 210 cases (105 as patients group presented with ischemic stroke and another 105 case as control group not suffering from ischemic stroke) were examined for TSH, T4 and T3. The period of data collection was from Jan. 2011 to the end of Jan. 2012. The patients were collected from the wards of neurology while the control group were collected from the out patients clinic, of Baghdad Teaching Hospital, Baghdad, Iraq.
Ischemic stroke was confirmed by their clinical picture and native brain CT scan. Exclusion and inclusion criteria, definition of variables and the consents from all patients were fulfilled.
Results: 8.6% of ischemic stroke patients showed hypothyroid pattern, 8.6% hyperthyroid pattern and 3.8% sick euthyroid pattern and these results were statistically significant as compared with control cases. 7.6% of patients had atrial fibrillation (AF) statistically of significant difference. Most cases of AF registered among patients with hyperthyroidism 60%. 12.7% of patients with hypothyroid pattern had statistically significant obesity and 8% of patients with sick euthyroid pattern had diabetes which was also significant.
Conclusions: Both hyperthyroidism and hypothyroidism might be considered as risk factors for developing ischemic stroke. Atrial Fibrillation may be a predictor for developing ischemic stroke especially in patients with hyperthyroidism. In hypothyroidism, there may be an association of several atherosclerotic risk factors with ischemic stroke. Sick euthyroid is not uncommon in patients with ischemic stroke which reflect the increase in physical stress associated with the insult.
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