Serological Study for TORCH Infections by ELISA Method in Women with Bad Obstetric History in Kerbala City
Kerbala Journal of Medicine,
2013, Volume 6, Issue 2, Pages 1621-1624
Abstractbackground: Bad obstetric history (BOH) implies previous unfavorable fetal outcome
in terms of two or more consecutive spontaneous abortions, early neonatal deaths,
stillbirths, intrauterine fetal deaths, intrauterine growth retardations and congenital
anomalies. Maternal infections transmissible in utero at various stages of gestation lead to
recurrent pregnancy wastage. Infections caused by TORCH –toxoplasma, rubella virus,
cytomegalo virus (CMV) and
herpes simplex virus (HSV) – is the major cause of BOH.
Objective(S): The study aimed to evaluate the incidence of TORCH infections in women
with bad obstetric history (BOH).
Patients &methods : The study included 130 women with bad obstetric history and 65
clinically normal women with previous normal full term deliveries who were attended to the
gynecological & obstetrical hospital from January to July 2012. Serological evaluation for
TORCH infections was carried out by IgM ELISA method.
Result: Seropositivity for toxoplasma was 39.23%, rubella 12.3%, cytomegalovirus 35.38%
and herpes simplex virus1.53%. Maximum percent cases of abortion (41.37%) Early neonatal
death (25%) congenital malformation (16.6%) was associated with toxoplasma infection.
Maximum percent of cases of abortion (36.20%) Early neonatal death (25 %) congenital
malformation (33.3%) was associated with cytomegalo infection. while (1.72%) and
(13.79%) maximum percent of cases of abortion associated herpes and rubella respectively
Conclusion(S): TORCH infections are associated with recurrent abortion, intrauterine growth
retardation, intrauterine death, preterm labor, early neonatal death, and congenital
malformation. Previous history of pregnancy wastages and positive serological reactions
during the current pregnancy must be considered while managing BOH cases so as to reduce
the adverse fetal outcome.
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