Effects of Type-2 Diabetes Mellitus on Serum Leptin, Insulin, Interlukin-8, and Lipid Profile
Kerbala Journal of Medicine,
Volume 4, Issue 9, Pages 1011-1018
Abstractbackground: Diabetes mellitus emerge as a developing global problem , insulin resistant occur to be prominent feature of type-2 diabetes mellitus, leptin hormone (which is a 167 amino acid protein synthesized in white adipocyte and directly proportionate with obesity) have a relationship with diabetes mellitus Type-2.while interlukin-8 (which is a chemotactic factor ) may play a role in obesity or type-2 diabetes mellitus.
Objective: The aim of this study is to:
1-Determine the serum levels of Leptin, Insulin, Interleukin-8 (IL-8) and Lipid
profiles in Type-2 diabetic Iraqi patients.
2-Evaluate the correlation between leptin, insulin, IL-8 and Lipid profiles in sera of Type-2 diabetes mellitus (T2DM) in Iraqi patients.
Materials and Methods: A total number of 95 (70 Type 2diabetic patients and 25
apparently normal subjects), (46male and 49 female) obtained from Al-Hussain
Teaching Hospital/ Karbala - Iraq between Oct. , 2010 – April , 2011 with age ranged
between (20-75) years how were divided into three groups: ( obese type-2 diabetic
patients, Non-obese type-2 diabetic patients, and Non-obese non-diabetic subjects )
.Obese diabetic patients was specified by body mass index, BMI ≥30kg/m2. Fasting
serum leptin, insulin, IL-8 ,and lipid profile have been determined. A pre-tested
questionnaire was designed to obtain information about age, gender, height, weight,
and past-medical history. Body Mass Index (BMI) and (BF%) were the only
anthropometric parameter specified.
Results and Discussion: The levels of each of leptin and insulin hormones, Cholesterol, LDL-cholesterol, TG, BMI and BF% were elevated markedly in diabetic patients compared with non-diabetic thin. Leptin hormone level shows a significant positive correlation with insulin hormone, LDL-cholesterol, BMI and BF%. The level of IL-8 was fluctuated and there is a non-significant positive correlation with increasing BMI. Significant differences were found in leptin mean values between male and female in which its levels is markedly elevated in females.
Conclusion: The results obtained in this study reveals significant elevations in serum leptin, insulin, cholesterol, and LDL-cholesterol with a non-significant decline in HDL-cholesterol in Type2 diabetic patients in comparison with normal subjects. Also there was a significant elevation in serum leptin level in females in comparison with males in both diabetic and control groups. There was a non-significant positive correlation between IL-8 and obesity. The results show a strong correlation between insulin resistant and leptin resistant.
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