Breast Cancers: Young Age the Significant Predictor……………..…………….…..
Kerbala Journal of Medicine,
Volume 4, Issue 9, Pages 950-956
AbstractBackground: The incidence of breast cancer in young women (age < 35) is low. The biology of the disease in this age group is poorly understood, and there are conflicting data regarding, the prognosis for these women compared to older patients.
Patients and methods: We retrospectively analyzed consecutive primary invasive breast cancer patients who underwent surgical procedures at our institution between 1990 and 2002. The younger age group was defined as patients aged <35 years at the time of diagnosis, the clinicopathological characteristics and treatment outcomes were compared between younger and older age groups.
Result: A total of 51 (12.5%) patients were aged <35. There was a significantly higher incidence of nuclear grade 3 and medullary histological-type tumors in younger patients compared to older patients. Axillary lymph node status, T stage, histological grade, and estrogen receptor status did not differ significantly between the two age groups. Younger patients had a greater probability of recurrence and death at all time periods, although there was no significant difference in disease-free survival between the two age groups.
In lymph node-negative patients, the younger group showed worse prognosis among lymph node-positive patients (p<0.001).
Conclusion: In multivariate analysis, young age remained a significant predictor of recurrence (p=0.010). Young age (<35) is an independent risk factor for relapse in operable breast cancer patients.
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