Coronary artery disease in young versus older adults in Hilla city: prevalence, clinical characteristics and angiographic profile
Kerbala Journal of Medicine,
Volume 5, Issue 11, Pages 1328-1333
AbstractBackground : Coronary artery disease, is a major cause of mortality and morbidity worldwide .It's incidence among young age groups is increasing rapidly.
Objectives : Coronary artery disease is now frequently encountered in young adult population. However, not many studies are available in this regard. Therefore, the present study was designed to evaluate the prevalence , clinical characteristics and angiographic features of patients ≤40 years of age with Coronary artery disease and compare them to patients >40 years.
Methods: this study was conducted at shaheed al muhrab cardiac center in Hilla city, all patients who had underwent coronary angiography in the catheterization laboratory were included in the study during the period april 2008 to July 2011. Patient who had history of revascularization procedure were excluded from the study. The patients were divided into two groups on the basis of age. The first group ( groupA) include patients 40 years and younger, while the second group ( group B) include patients older than 40 years.
Results:of the total 803 patients , 58(7.2%) were ≤40 years old (groupA)and 745 (92.8%) were older than 40 years (groupB).Smoking , premature CAD and hyperlipidemia were statically significant risk factors in patients≤40 years old (groupA) 24.2%,19% ,17.2% respectively compared to 13.2%,10.3%, 10.7% in patients older than 40 years (groupB), whereas hypertension, diabetes mellitus and obesity were more prevalent in( Group B), 27%,22.8%, 16% respectively, compared to (Group A) , 15.5%,13.8%, 10.3% respectively (p<0.001) .7.2% of patient who have evidence of CAD proved by coronary angiography were in age group ≤40 years. Younger patients ( groupA) tends to have single vessel disease 56.9% compared to older patients ( group B) 24.4%, and the reverse is true in regards to three vessel disease 44.2% vs19%.
Conclusions: 7.2% of angiographically documented cases of coronary artery disease patients were 40 years & younger in age ,this percentage was high among our studied population . smoking , family history of premature Coronary artery disease & hyperlipidemia were significantly associated with Coronary artery disease in young patients(p<0.001) Young patients tends to have single vessel disease while older ones tends to have three vessel disease(p<0.001)
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