Sex Difference as a Risk Factor for Gallston disease
Kerbala Journal of Medicine,
2012, Volume 5, Issue 11, Pages 1250-1254
Abstractackground: Gallstone disease is a common clinical entity affecting the adult population of both sexes.
Aim of the study: The objective of present investigation was to compare the impact of sex, age and BMI on the gallstone disease.
Subject and Methods: A total of 150 subjects whom suffered from gallstones visible by ultrasound were considered as cases aged (48.52 ± 9.534) years comprised from 19 men and 131 women and subjects negative for gallstones were classified as controls, consist of 50 parsons aged (27.96 ± 6.72) years, 14 males and 36 females.
Results and Discussion: The results of analysis of individual factors and their association with women were affected nearly fivefold than men (5:1). The objectives of present investigation were to compare the impact of sex, age and BMI on the gallstone disease. In order to identify the risk factors, we further performed a multivariate logistic regression analysis. The factors significantly (OR 5.40, 95%CI 0.77-46.99; p = 0.05, OR 2.80, 95% 0.86-16.12; p = 0.04) associated with gallstones disease were an age 30-49 and an age > 50 years (OR 8.25, 1.17-92.97; p= 0.01, OR 21.94, 6.72-97.26; p= 0.0001) for males and females respectively. High body mass index, however was detected as an independent risk factor for gallstone disease in females ( OR 1.96,0.88- 4.42; p = 0.05).In the male population, no such association was present.
Conclusion: Present studies have defined the role of sex difference on the formation of gallstone.
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