• Pathological Study Of Renal Cell Carcinoma By Expression Of Vascular Endothelial Growth Factor (VEGF) And P53 (Immunohistochemical approach…
Kerbala Journal of Medicine,
2011, Volume 4, Issue 10, Pages 1128-1132
Abstractbackground: Renal cell carcinomas (RCC) represent about 1-3% of all visceral cancers. There are 30,000 new cases per year and 12,000 deaths from the disease in USA (1).
Aim: To estimate the rate of VEGF & P53 immunohistochemical overexpression in RCC in relation to histological types of tumor.
Methods: Fomalin fixed, paraffin-embedded blocks from 48 patients (28 male and 20 female) with RCC included in this study. A group of 12 patients with non specific inflammation –pyelonephritis were included as a control group. LSAB+ (Labeled Strept-Avidin Biotin) method was employed for immunohistochemical detection of VEGF & P53.
Results: In assessment of the correlation of VEGF overexpression in RCC with histological types, there is correlation between the intensity of VEGF expression & classical type as (R= 0.618) while in other histological types no correlation & no significant difference (p>0.05) between them. In assessment of the correlation of P53 overexpression in RCC there is a negative correlation (R=-0.843) in classical, in papillary (R=-0.674) & no significant difference between them (p>0.05).
Conclusion: these finding provide further evidence for the role of VEGF & P53 in the carcinogenesis of RCC. However both markers not well correlated with histological types of the tumor.
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