Electrolytes & [H+] Disturbances in Peptic Ulcer Patients
Kerbala Journal of Medicine,
2009, Volume 2, Issue 4, Pages 447-451
Abstractin the body even a very small pH changes are important and result in change in body
physiology . We describe in our study the presence of alteration in electrolytes and acid-base
status in patients with peptic ulcer disease.
The study was carried out over a period of three years. 273 patients with peptic ulcer disease
diagnosed on endoscopy , of these 228 duodenal ulcer and 45 gastric ulcer , in addition 84
subjects were considered as a healthy control .
20 ml of gastric juice obtained for analysis and 5 ml blood sample were taken and pH
determination and[ H+ ]estimated by electric sensitive method including the use of electronic
sensitive pH – meter. The pH – electrode was initially calibrated in buffer solution of pH 7 ( Ian
1969 ). Also the total acidity of gastric effluents were estimated by titration to pH 7 with 0.1
NaOH. The K+ and Na+ concentrations determined by using flame photometric method ( Sood
1987) The results of the study show that DU patients had significantly lower gastric secretion
pH and higher H+ concentration in the blood than normal control subjects and total acidity of
gastric secretion also was higher than control.
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