Role of Interferon –Gamma and Interleukin -4 in Immunepathogenesis of Chronic Hepatitis C Virus……………..
Kerbala Journal of Medicine,
2009, Volume 2, Issue 4, Pages 510-518
Abstractthis study was carried out to investigate some immunological aspects in Iraqi patients with
hepatitis C virus infection compared to patients and healthy control groups.The study
included (50) patients with chronic hepatitis C infection referred to ((The
gastroenterology and hepatology center) (Medical City- Baghdad )), with age range from (8-75)
years , (20) patients with non viral chronic liver diseases and (20) healthy control groups.
classified the HCV patients into five stages according to their fibrosis stage: five patients in stage
0, (14) patients in stage 1, (12) patients in stage 2, (12) patients in stage 3, (7) patients in stage 4.
With application of ELISA technique, serum levels of Interleukin -4(1L-4), and Interferon –
gamma (IFN-γ ) were measured in (50) patients with HCV infection compared to that of control
groups which include (20) patients with non viral liver pathologies (patients control) and (20)
healthy control groups. The mean serum level of 1L-4 and IFN-γ showed a significant increase in
patient with HCV as compared with patients control and healthy control groups. In addition,
significant linear correlation between IFN-γ with fibrosis stages, while inverse correlation
between 1L-4 and fibrosis stages in HCV patients.
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