Comparative Evaluation of Ketorolac and Diclofenac for Pain Relief in Acute Lumbar Disc Prolapse.........
Kerbala Journal of Medicine,
2009, Volume 2, Issue 4, Pages 486-490
Abstractthe study aimed to study the efficacy and safety of ketorolac tromethamine compared to
diclofenac sodium in patients with acute lumbar disc prolapse.
Thirty three patients were included as subjects in the study, 17 of them received ketorolac
15 mg intramuscularly (IM) and 16 received 75 mg diclofenac IM. Analgesic efficacy was
assessed using the visual analogue scale (VAS) 1, 3 and 6 hours after drug injection and side
effects by enquiry and reporting whenever it occurred.
Ketorolac showed equi-analgesic effect as diclofenac at 1 3 and 6 hours post-injection
and was as safe as diclofenac in the mentioned doses.
In conclusion: Ketorolac, as doe’s diclofenac, appeared to be a safe, effective drug in the
treatment of pain in cases of acute lumbar disc prolapse.
Further studies for more assessment of this drug in higher doses and longer durations and
its use in other acute musculoskeletal conditions are recommended. We also suggest further
investigations regarding the commonly used pain scales like VAS to highlight the influence of
psychological or other social conditions in our community that may affect the expression of these
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