Serum levels of Interleukin 6 and Homocysteine in Type 2 Diabetic Patients with renal failure complication
Kerbala Journal of Medicine,
Volume 3, Issue 6, Pages 804-811
Abstractackground: Cardiovascular diseases are more common among type 2 diabetic
patients than healthy subjects without a family history of diabetes. Serum
interleukin-6 (IL-6) and homocysteine (Hcy) levels are markers of endothelial
dysfunction and cardiovascular disease.
Aim: this study demonstrated to evaluate levels of IL-6, Hcy and their association
with cardiovascular risk in type 2 diabetic patients with renal failure complication.
Material & Methods: The circulating IL-6 and Hcy levels were measured in 45 type
2 diabetic patients and 25 control subjects without a known family history of diabetes.
The BIOSOURCE IL-6 ELISA kit used to measure IL- 6, high performance liquid
chromatography HPLC technique used to measure serum Homocystein, and
enzymatic methods are used for blood suger, urea, creatinine, and lipid profile
Results: A significant differences were found in serum levels of IL6 and Hcy
between the two groups diabetic and healthy control (p>0.05). IL6 levels correlated
significantly with Hcy (p=0.02), hemoglobin A1C (p=0.03), and serum Hcy correlated
significantly with HbA1C (p=0.03) levels in patients with type 2diabetes mellitus.
Conclusion: These results suggest that serum IL-6 and Hcy levels do not directly
contribute to the development of endothelial dysfunction and cardiovascular risk
factors in type 2 diabetic patients with renal failure complication.
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