Correlation between H Pylori Infection and Nonalcoholic Fatty Liver Disease in Karbala City
Kerbala Journal of Medicine,
2018, Volume 11, Issue 2, Pages 3964-3977
Abstractbackground: NAFLD patients had higher anti IgG H pylori and might be a clue that H pylori infection had a strong link the pathogenesis of early stage NAFLD mostly had simple steatosis. H pylori infection had a role in pathogenesis of IR and NAFLD. H pylori is strong inducer of pro inflammatory cytokine (IL6, IL8, TNF- α).Serum triglyceride was higher in H pylori positive group and NASH. Recent study have investigated weather H pylori induce insulin resistance mediated through fetuin which decrease in patients with sero positive Hpylori IgG patients.
Patient and method: Fifty six patients were collecting randomly as a case of fatty liver by ultrasound In Imam AL- Hussain Medical City in Karbala .Obese, DM, alcoholic patients, renal and hepatic diseases were exclude from this study. Fasting blood sample was taken and sent for IgG antibody H pylori, lipid profile, liver function test including ALT and AST.
Result: The mean age of patients was 45+10 and majority (65%) was females.
(67)% of patients who were fatty liver had Hpylori sero positive IgG (p value<0.05).
(66)% of patients who were fatty liver had normal liver function ALT mean±SD(31±7) and only 34% had increased liver function, ALT mean SD±(110±13)with p value<0.01.
(71)% of patients who were fatty liver and H pylori sero positive IgG had normal liver function mostly ALT mean±SD (29±10) in comparism with 29% who had increase liver function mostly ALT mean ±SD(98±18) p value <0.01.
(83)% of fatty liver patients had hyperlipidaemia mean±SD (290±20), (395±22) respectively p value<0.01.
(75)% of fatty liver patients with H pylori sero positive IgG had hyperlipidaemia mean±SD (279±15),(320±20) respectively p value <0.01.
Conclusion This study shown significant correlation between chronic H pylori infection and NAFLD .The pathogenic mediator include fetuin-A, TNF-α and adiponectin and on long term IR.
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