Association of Adiponectin Gene Promoter Polymprphism (rs266729) With Ischemic Heart Diseases
Kerbala Journal of Medicine,
Volume 11, Issue 1, Pages 3889-3893
Abstractbackground: Ischemic Heart Disease is a group of diseases of the blood vessels supplying the heart muscle. Adiponectin is a protein secreted by adipocyte with insulin-sensitizing, Anti-inflammatory and anti-atherogenic properties. Several studies have shown that polymorphisms within the adiponectin gene can be associated with Ischemic heart disease.
Aim: The aim of the present study was to evaluate the impact of (rs266729) SNP in the promoter region of the ADIPOQ gene on the occurrence of Ischemic heart disease (IHD).
Methods: The study included 150 patients with IHD randomly selected based on World Health Organization (WHO) guideline and 150 as controls group. DNA was extracted from blood and genotyped by PCR-RFLP by using (Hha1) enzyme.
Result: The frequency of G allele of rs266729 (C/G) polymorphism was significantly (p=0.0001) in IHD (19.6%) compared with control (13.3%). The homozygous genotype (GG) significantly (0R=1.71, CI 95%=0.65-4.96, P= 0.0001) increased the risk of Ischemic Heart Disease compared with wild type (CC) after adjustment age, sex, and BMI, furthermore the heterozygous (CG) genotype significantly (0R=1.61, CI 95%=0.96-2.87, P= 0.0001) raised the risk of Ischemic Heart Disease.
Conclusion: Adiponectin gene polymorphism rs266729 is involved in the pathogenesis Ischemic heart disease.
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