The Pathophysiological Bases of Obsessive Compulsive Disorders
Kerbala Journal of Medicine,
Volume 10, Issue 3, Pages 3963-3972
AbstractPurpose of review
This review considers the neurobiological aspects and the genetics of the Obsessive-compulsive disorders (OCD). The recent advances in OCD research showed the increasing role of alteration in both the molecular and cellular mechanisms. These altered physiological mechanisms were clinically evident through phenomenology, neuropsychology, neuroimmunology, and neuro-imagery among the patients with OCD. The most consistent finding throughout the researches was the involvement of various cortical and subcortical regions, especially the orbitofrontal cortex (OFC), the anterior cingulate cortex (ACC), the dorsolateral prefrontal cortex (DLPC), the head of the caudate nucleus and the thalamus in the development of OCD. Neuropsychiatric genetic literatures have been expanded to highlight the genetic bases for the development of OCD and their role with various environmental conditions in determination of the disease prognosis and resistance to treatments. This review also discussed uncommon etiologies for OCD, like infections and traumatic brain injuries (TBI). These findings will provide new approaches for better diagnostic and treatment advances.
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