Prevalence of Celiac Disease in Dyspeptic Patients
Kerbala Journal of Medicine,
2017, Volume 10, Issue 3, Pages 3833-3840
Abstractbackground:Celiac disease (CD) is a disorder of small bowel malabsorption, occur upon exposure to gluten, CD appears to represent a spectrum of presentations: ranging from classical type (most commonly describe), to atypical form found in the setting of another presentation e.g.: iron deficiency, osteoporosis (most patients have it). The diagnosis of CD in adults is classically made on clinical suspicion but firm diagnosis can only be established by small intestinal biopsies and serologic markers
Objectives: to estimate the prevalence of celiac disease in patients with dyspepsia Methods: Any patient had dyspepsia, older than 15 years were tested for anti-tissue transglutaminase antibody and underwent upper gastroduodenoscopy.Four endoscopic biopsies were taken from each patient and sent for histopathological examination and classified according to modified Marsh's classification.
Results: Among 157 patients who enrolled in study, 17 patients were labeled as celiac disease: 16 of them has histopathologic changes (Marsh II and above) and 1 patient was normal mucosa, 15 patients from them were positive for tTG antibody and 2 patients were negative.
Conclusions: any patients diagnosed with functional dyspepsia and sent for endoscopy, should routinely had biopsy of the descending duodenum. Particular attention to females with dysmotility or indeterminate dyspepsia.
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