Immunophenotyping of Mature B-Cell Neoplasms in Correlation with Morphological Diagnosis
Kerbala Journal of Medicine,
Volume 9, Issue 1, Pages 2397-2402
Abstractbackground: Mature B-cell neoplasms include a number of disease entities arising from mature B lymphocytes which involve primarily the blood, bone marrow (BM) and lymphoid organs such as the lymph nodes and spleen.
Although there are difficulties in separating CLL from some NHL, the distinction is important because prognostic and therapeutic differences exist.
Immunophenotyping (IPT) has become an essential tool to confirm the diagnosis and to separate CLL from other lymphoid malignancies.
Objectives: To express the difference between the IPT& morphology with morphology alone to reach definite diagnosis in mature B- cell neoplasm.
Methods: BM biopsies of fifty five adult patients with CLL and leukemic phase of NHL were collected from December 2010 to April 2011; fifty of them were retrospectively while five of them were prospectively collected.
Results: In this study, Twenty six out of 29 CLL patients were confirmed as CLL by IPT while the rest three cases diagnosed as NHL rather than CLL and 25 out of 26 NHL cases were confirmed by IPT and only one case diagnosed as CLL.
Conclusions: This study revealed that the IPT has important diagnostic role in the subclassification of mature B-cell neoplasms also revealed that the IPT technique in conjunction with morphology have more precise role than morphology alone in the diagnosis of mature B-cell neoplasms.
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