Comparative Study of Pap Smear and Cervical Biopsy Findings
Kerbala Journal of Medicine,
Volume 8, Issue 2, Pages 2272-2281
Abstractbackground: Pap smear is the most important screening test for premalignant and malignant non invasive carcinoma of uterine cervix. Most authorities agree that patients with singinifiatly abnormal pap smear, such as cervical intraepithelial neoplasia (CIN) needs colposcopic evaluation and biopsy, this is especially in high grade cytological abnormalities (CIN II & III) ( moderate and severe dysplasia.
Objective: To assess the accuracy of pap smear in detection of premalignant changes of cervical epithelium and correlate the finding of this cytological method with the finding of the biopsy material.
Materials and methods: Aprospective study which includes 100 non-pregnant females aged 16-69 years who had symptoms. The interpretation of cytological results was descriptive done in the Bethesda System terminology 2001 (Solomon and Nayar, 2004), which includes the following entities: NILM , ASC-US, ASC-H, HSIL & LSIL. Also all cases submitted for biopsy and subsequent histopathological examination.
Results & Discussion: Results of pap smear cytopathological examination:
According to Bethesda, the results of NILM, ASCUS, ASC-H, LSIL, HSIL, and SCC were 53% ,4 % , 5% , 24% , 7% , and 2% respectively.
Results of histopathological examination:
Results revealed that benign changes were found in 63 of 100 (63%) which show chronic cervicitis and endocervical polyp , CIN 1 in 20%, CIN 2 in 9%, CIN 3 in 5%, CIS in 1%, and SCC in 2%.
In our study, 10.26% of NILM cytology cases were false negative, which puts us in an intermediate position as compared to many other studies
Conclusion: Pap smear test was found to be equally sensitive to histopathological examination for the early detection of different cervical lesions.
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